DOESP 22/09/2026 - Diario Oficial do Estado de Sao Paulo - Executivo Atos de Gestão e Despesas

TEXTO OFICIAL · ÍNTEGRA

7/202 - Diário Oficial do Estado de São Paulo

Volume 136, nº 181, Caderno Executivo, Atos de Gestão e Despesas, terça-feira, 22 de setembro de 2026

3 – DEPARTAMENTO: BIOLOGIA MOLECULAR
DISCIPLINA/CONJUNTO DE DISCIPLINAS BIOLOGIA MOLECULAR
APLICADA AO TRANSPLANTE RENAL
PROGRAMA:

• �. Bases fisiológicas e moleculares da morte encefálica e seus impactos na viabilidade do enxerto renal

• �. Mecanismos fisiológicos e moleculares da lesão de isquemiareperfusão no transplante renal

• �. Inflamação estéril e ativação da imunidade inata no transplante renal

• �. Inflamassoma e mecanismos moleculares da resposta inflamatória no transplante renal

• �. Estratégias terapêuticas para modulação da resposta inflamatória e proteção do enxerto renal

• �. Biomarcadores moleculares na avaliação da qualidade e da viabilidade do enxerto renal

• �. Bases moleculares da função retardada do enxerto (Delayed Graft Function - DGF)

• �. Mecanismos moleculares da preservação e do recondicionamento do enxerto renal

• �. Modelos experimentais aplicados à medicina translacional em transplante renal

• ��. Medicina translacional no transplante renal: da investigação molecular ao desenvolvimento de estratégias terapêuticas

• �. Pratschke J, et al. Accelerated rejection of renal allografts from brain-dead donors. Ann Surg. 2000.

• �. de Vries DK, et al. Donor brain death predisposes human kidney grafts to a proinflammatory reaction after transplantation. Am J Transplant. 2011.

• �. Zitur LJ, et al. Brain death enhances activation of the innate immune system and leads to reduced renal metabolic gene expression. Transplantation. 2019.

• �. Schnuelle P, et al. Donor organ intervention before kidney transplantation. Am J Transplant. 2019.

• �. Zhao H, et al. Ischemia-reperfusion injury reduces long-term renal graft survival: mechanism and beyond. EBioMedicine. 2018.

• �. Lasorsa F, et al. Ischemia-reperfusion injury in kidney transplantation: mechanisms and potential therapeutic targets. Int J Mol Sci. 2024.

• �. Dugbartey GJ. Cellular and molecular mechanisms of cell damage and cell death in ischemia-reperfusion injury in organ transplantation. Mol Biol Rep. 2024.

• �. Sanz AB, et al. Regulated cell death pathways in kidney disease. Nat Rev Nephrol. 2023.

• �. Land WG, et al. Transplantation and damage-associated molecular patterns (DAMPs). Am J Transplant. 2016.

• ��. Gong T, et al. DAMP-sensing receptors in sterile inflammation and inflammatory diseases. Nat Rev Immunol. 2020.

• ��. Braza F, et al. Role of TLRs and DAMPs in allograft inflammation and transplant outcomes. Nat Rev Nephrol. 2016.

• ��. Florim GMS, et al. Activation of HMGB1-TLR4 pathway and inflammasome contribute to enhanced inflammatory response in extended criteria and kidneys with KDPI≥85%. Transplantation. 2020.

• ��. Swanson KV, et al. The NLRP3 inflammasome: molecular activation and regulation to therapeutics. Nat Rev Immunol. 2019.

• ��. Granata S, et al. Inflammasome pathway in kidney transplantation. Front Med. 2023.

• ��. Su X, et al. NLRP3 inflammasome: a potential therapeutic target to minimize renal ischemia/reperfusion injury during transplantation. Transpl Immunol. 2022.

• ��. Anders HJ. Of inflammasomes and alarmins: IL-1β and IL-1a in kidney disease. J Am Soc Nephrol. 2016.

• ��. Coll RC, et al. A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases. Nat Med. 2015.

• ��. Corcoran SE, et al. Pharmacological inhibition of the NLRP3 inflammasome with MCC950. Pharmacol Rev. 2021.

• ��. Bogdanova D, et al. Targeting interleukin-1 signaling for renoprotection. Front Immunol. 2025.

• ��. Gonçalves NDN, et al. Targeting kidney inflammation after brain death and cold storage: investigating the potential of an NLRP3 inflammasome inhibitor (MCC950) for preconditioning donor kidneys. Transplantation. 2025.

• ��. Florim GMS, et al. Activation of HMGB1-TLR4 pathway and inflammasome contribute to enhanced inflammatory response in extended criteria and kidneys with KDPI ≥85%. Transplantation. 2020.

• ��. Gonçalves NN, et al. Distinct global DNA methylation and NF-KB expression profile of preimplantation biopsies from ideal and non-ideal kidneys. J Nephrol. 2022.

• ��. Heylen L, et al. Ischemia-induced DNA hypermethylation during kidney transplant predicts chronic allograft injury. J Am Soc Nephrol. 2018.

• ��. Lantinga VA, et al. Biomarkers in ex vivo kidney perfusion: a shift toward omics diagnostics. Transplantation. 2026.

• ��. de Sandes-Freitas TV, et al. Exploring the causes of the high incidence of delayed graft function after kidney transplantation in Brazil. Transpl Int. 2021.

• ��. Guerrieri D, et al. Gene expression profile in delayed graft function. Mediators Inflamm. 2014.

• ��. Lentine KL, et al. OPTN/SRTR Annual Data Report: Kidney. Am J Transplant. 2023.

• ��. Querard AH, et al. Expanded criteria donor versus standard criteria donor kidney transplantation: systematic review and meta-analysis. Transpl Int. 2016.

• ��. Moers C, et al. Machine perfusion or cold storage in deceaseddonor kidney transplantation. N Engl J Med. 2009.

• ��. Husen P, et al. Oxygenated end-hypothermic machine perfusion in expanded criteria donor kidney transplant. JAMA Surg. 2021.

• ��. Hosgood SA, et al. Normothermic machine perfusion versus static cold storage. Nat Med. 2023.

• ��. Franchin B, et al. Normothermic kidney perfusion: current status and future perspectives. Kidney Int Rep. 2025.

��. van Leeuwen LL, et al. Targeted delivery using machine perfusion reduces fibrogenesis in an ex vivo renal model. Br J Pharmacol. 2024.

• ��. Weissenbacher A, et al. Twenty-four-hour normothermic perfusion of discarded human kidneys. Am J Transplant. 2019.

• ��. Marzochi LL, et al. In situ perfusion with MCC950 modulates the pyroptosis-related axis and DAMP-TLR4 signaling. Eur J Pharmacol. 2026.

• ��. Marzochi LL, et al. IL-1 receptor blockade modulates inflammation during sequential perfusion in ex vivo porcine kidneys. Transplantation. 2026 (no prelo).

• ��. Reese PP, et al. New solutions to reduce discard of kidneys donated for transplantation. J Am Soc Nephrol. 2016.

• ��. Land WG, Linkermann A. Regulated cell death and DAMPs as biomarkers and therapeutic targets in normothermic perfusion of transplant organs. Front Transplant. 2025.

• ��. Schnuelle P, et al. Donor organ intervention before kidney transplantation. Am J Transplant. 2019.

• ��. Associação Brasileira de Transplante de Órgãos (ABTO). Registro Brasileiro de Transplantes. 2025.

• �. American Journal of Transplantation

• �. Transplantation

• �. Kidney International

• �. Journal of the American Society of Nephrology (JASN)

• �. Clinical Journal of the American Society of Nephrology (CJASN)

• �. Nature Reviews Nephrology

• �. Transplantation Proceedings

1. Cardiologia – Medicina Baseada em Evidências

2. Estratificação de Risco e Escores Prognósticos em Cardiologia

3. O Impacto da Pesquisa Clínica na Prática Cardiológica

4. Biomarcadores em Cardiologia

5. Controle Glicêmico, Diabetes Mellitus e Doenças Cardiovasculares

6. Dislipidemias e Doenças Cardiovasculares

7. Obesidade e Doenças Cardiovasculares

8. Síndrome Coronária Crônica

9. Cardiomiopatia Chagásica: Estratificação de Risco e Desfechos

Clínicos

1. Manejo Terapêutico da Insuficiência Cardíaca Crônica

2. Blumenthal RS, et al. 2026 ACC/AHA/AACVPR/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Dyslipidemia: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. J Am Coll Cardiol. 2026 May 19;87(19):2624-2757. doi: 10.1016/j.jacc.2025.11.016. Epub 2026 Mar 13. PMID: 41824590.

3. Ndumele CE, et al. 2026 AHA/ACC/ADA/ASN Guideline for the Prevention, Detection, Evaluation, and Management of CardiovascularKidney-Metabolic Syndrome: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. J Am Coll Cardiol. 2026 Jun 9;87(22S):e1889-e2007. doi: 10.1016/j.jacc.2026.03.056. PMID: 42265997; PMCID: PMC13399222.

4. Kittleson MM, et al. Management of Heart Failure With Preserved Ejection Fraction: 2026 ACC Expert Consensus Decision Pathway: A Report of the American College of Cardiology Solution Set Oversight Committee. J Am Coll Cardiol. 2026 Jul 23:S0735-1097(26)06875-0. doi: 10.1016/j.jacc.2026.06.018. Epub ahead of print. PMID: 42494134. 4. Walsh MN, et al. AHA/ACC/ESC/WHF Expert Consensus Document: Second Universal Definition of Heart Failure (2026). J Am Coll Cardiol. 2026 Jun 29:S0735-1097(26)06703-3. doi: 10.1016/j.jacc.2026.05.036. Epub ahead of print. PMID: 42370864.

5. Mach F et al. 2025 Focused Update of the 2019 ESC/EAS Guidelines for the management of dyslipidaemias. Eur Heart J. 2025 Nov 7;46(42):43594378. doi: 10.1093/eurheartj/ehaf190. Erratum in: Eur Heart J. 2026 Feb 11;47(6):697. doi: 10.1093/eurheartj/ehaf1036. PMID: 40878289.

6. Rached FH, et al. Brazilian Guideline on Dyslipidemias and Prevention of Atherosclerosis 2025. Arq Bras Cardiol. 2025 Dec 1;122(9):e20250640. Portuguese, English. doi: 10.36660/abc.20250640. PMID: 41379178; PMCID: PMC12674852.

7. Saraiva JFK, et al. 2025 Brazilian Evidence-based Guideline on the Management of Obesity and Prevention of Cardiovascular Disease and Obesity-Associated Complications: A Position Statement by Five Medical Societies. Arq Bras Cardiol. 2025 Dec 1;122(9):e20250621. Portuguese, English. doi: 10.36660/abc.20250621. PMID: 41379177; PMCID: PMC13148858.

8. Vrints C, et al. 2024 ESC Guidelines for the management of chronic coronary syndromes. Eur Heart J. 2024 Sep 29;45(36):3415-3537. doi: 10.1093/eurheartj/ehae177. Erratum in: Eur Heart J. 2025 Apr 22;46(16):1565. doi: 10.1093/eurheartj/ehaf079. PMID: 39210710.

9. McEvoy JW, et al. 2024 ESC Guidelines for the management of elevated blood pressure and hypertension. Eur Heart J. 2024 Oct 7;45(38):3912-4018. doi: 10.1093/eurheartj/ehae178. Erratum in: Eur Heart J. 2025 Apr 7;46(14):1300. doi: 10.1093/eurheartj/ehaf031. Erratum in: Eur Heart J. 2025 Dec 1;46(45):4949. doi: 10.1093/eurheartj/ehaf659. PMID: 39210715.

10. Byrne RA, et al. 2023 ESC Guidelines for the management of acute coronary syndromes. Eur Heart J. 2023 Oct 12;44(38):3720-3826. doi: 10.1093/eurheartj/ehad191. Erratum in: Eur Heart J. 2024 Apr 1;45(13):1145. doi: 10.1093/eurheartj/ehad870. PMID: 37622654.

11. Arbelo E, et al. 2023 ESC Guidelines for the management of cardiomyopathies. Eur Heart J. 2023 Oct 1;44(37):3503-3626. doi: 10.1093/eurheartj/ehad194. PMID: 37622657.

12. Marin-Neto JA, et al. SBC Guideline on the Diagnosis and Treatment of Patients with Cardiomyopathy of Chagas Disease 2023. Arq Bras Cardiol. 2023 Jun 26;120(6):e20230269. English, Portuguese. doi: 10.36660/abc.20230269. PMID: 37377258; PMCID: PMC10344417. 13. Jatene, Ieda B.; Ferreira, João Fernando M.; Drager, Luciano F.; et al. Tratado de cardiologia SOCESP. 5. ed. Barueri: Manole, 2022. E-book. p.Capa. ISBN 978655765182. Disponível em: https://integrada.minhabiblioteca.com.br/reader/books/978655765182/. Acesso em: 07 ago. 2026.

13. Marx N, et al. 2023 ESC Guidelines for the management of cardiovascular disease in patients with diabetes. Eur Heart J. 2023 Oct 14;44(39):4043-4140. doi: 10.1093/eurheartj/ehad192. Erratum in: Eur Heart J.

2023 Dec 21;44(48):5060. doi: 10.1093/eurheartj/ehad774. Erratum in: Eur Heart J. 2024 Feb 16;45(7):518. doi: 10.1093/eurheartj/ehad857. PMID: 37622663.

1. Arnett DK, et al. 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. J Am Coll Cardiol. 2019 Sep 10;74(10):e177-e232. doi: 10.1016/j.jacc.2019.03.010. Epub 2019 Mar 17. Erratum in: J Am Coll Cardiol. 2019 Sep 10;74(10):1429-1430. doi: 10.1016/j.jacc.2019.07.011. Erratum in: J Am Coll Cardiol. 2020 Feb 25;75(7):840. doi: 10.1016/j.jacc.2019.12.016. PMID: 30894318; PMCID: PMC7685565. 16. Rothman, Kenneth; Greenland, Sander; Lash, Timothy. Epidemiologia moderna. 3. ed. Porto Alegre: ArtMed, 2011. E-book. p.Cover. ISBN 9788536325880. Disponível em: https://integrada.minhabiblioteca.com.br/reader/books/9788536325880/. Acesso em: 07 ago. 2026.

2. Braunwald Tratado de Doenças Cardiovasculares. 11. ed. Rio de

Janeiro: Guanabara Koogan, 2022. 2 v.

�. ▪ New England Journal of Medicine (NEJM)

• �. ▪ The Lancet

�. ▪ European Heart Journal (EHJ)

• �. ▪ Journal of the American College of Cardiology (JACC)

• �. ▪ Circulation

• �. ▪ Journal of the American Medical Association (JAMA)

• �. ▪ British Medical Journal (BMJ)

• �. ▪ JAMA Cardiology

• �. ▪ European Journal of Heart Failure

• ��. ▪ Atherosclerosis

• ��. ▪ Arquivos Brasileiros de Cardiologia

• ��. ▪ Cochrane Database of Systematic Reviews

• ��. ▪ Journal of Clinical Epidemiology

• ��. ▪ Statistics in Medicine

• ��. ▪ BMJ Evidence-Based Medicine

5 – DEPARTAMENTO: DOENÇAS DERMATOLÓGICAS, INFECCIOSAS E
PARASITÁRIAS
DISCIPLINA: DOENÇAS INFECCIOSAS E PARASITÁRIAS
PROGRAMA

�. Dengue grave: mecanismos fisiopatogênicos, disfunção endotelial e determinantes da evolução clínica

• �. Diagnóstico da dengue: integração entre apresentação clínica, epidemiologia e métodos laboratoriais

• �. Chikungunya: espectro clínico, mecanismos de persistência

�. Febre amarela: patogênese, manifestações clínicas, diagnóstico e estratégias de prevenção �. Tuberculose ativa: avanços e desafios no diagnóstico microbiológico, molecular e clínico-radiológico �. Tratamento da tuberculose: fundamentos terapêuticos, monitoramento e manejo de eventos adversos �. Infecção pelo HIV: história natural, imunopatogênese e manifestações clínicas ao longo da evolução da doença �. Terapia antirretroviral e resistência do HIV: princípios, estratégias terapêuticas e interpretação da falha virológica �. Micoses sistêmicas em pacientes imunocomprometidos: abordagem clínica, diagnóstica e terapêutica da criptococose e da histoplasmose

��. Febre maculosa: aspectos ecoepidemiológicos, reconhecimento clínico precoce e desafios no diagnóstico e tratamento

• �. BLASER, M. J.; COHEN, J. I.; HOLLAND, S. M. (eds.). Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 10. ed. Philadelphia: Elsevier, 2025.

• �. LONGO, D. L. et al. (eds.). Harrison's Principles of Internal Medicine. 22. ed. New York: McGraw Hill, 2025.

• �. BRASIL. Ministério da Saúde. Secretaria de Vigilância em Saúde e Ambiente. Guia de Vigilância em Saúde. 6. ed. rev. Brasília: Ministério da Saúde, 2024. 3 v.

�. WORLD HEALTH ORGANIZATION. WHO guidelines for clinical management of arboviral diseases: dengue, chikungunya, Zika and yellow fever. Geneva: World Health Organization, 2025.

�. WORLD HEALTH ORGANIZATION. Consolidated guidelines on HIV prevention, testing, treatment, service delivery and monitoring: recommendations for a public health approach. Geneva: World Health Organization, 2021.

• �. PLoS Neglected Tropical Diseases

• �. Clinical Infectious Diseases

• �. Emerging Infectious Diseases

• �. Journal of Clinical Virology

• �. Journal of Medical Virology

6 - DEPARTAMENTO: DOENÇAS DERMATOLÓGICAS, INFECCIOSAS E
PARASITÁRIAS
DISCIPLINA: MICROBIOLOGIA COM ÊNFASE EM UMA SÓ SAÚDE
PROGRAMA:

• �. Doenças por bactérias Gram-negativas de transmissão hídrica e alimentar

• �. Doenças por bactérias Gram-positivas de transmissão hídrica e alimentar

• �. Protozooses de transmissão hídrica e alimentar

• �. Helmintoses de transmissão hídrica e alimentar

• �. Viroses de transmissão hídrica e alimentar

• �. Transmissão da resistência antimicrobiana por animais de produção

• �. Transmissão da resistência antimicrobiana por vegetais

• �. Helmintoses causadas pela falta de acesso ao saneamento básico que não as de transmissão hídrica e alimentar

• �. Doenças bacterianas zoonóticas e ambientais sob a perspectiva de Uma Só Saúde

��. Vigilância epidemiológica integrada e genômica em Uma Só Saúde

�. BROOKS, Geo F.; CARROLL, Karen C.; BUTEL, Janet S.; MORSE, Stephen A.; MIETZNER, Timothy A. Microbiologia Médica de Jawetz, Melnick & Adelberg. 26. ed. Porto Alegre: AMGH Editora LTDA, 2014.

Este documento pode ser verificado pelo código E.2026.09.22.1.7.1 em http://www.doe.sp.gov.br/autenticidade

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